Journal of Pharmacology and Experimental Therapeutics

Title Publication Date Language Citations
Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention2003/01/01English824
Functional Selectivity and Classical Concepts of Quantitative Pharmacology2006/06/27English789
The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development2003/06/12English765
Oxidative Stress and the Central Nervous System2016/10/17English709
Role of Tyrosine Kinase Inhibitors in Cancer Therapy2005/07/07English665
Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors2002/07/01English629
Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker2012/08/10English621
Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy2003/05/06English606
Novel Antiangiogenic Effects of the Bisphosphonate Compound Zoledronic Acid2002/09/01English562
Mitochondrial Dysfunction in Neurodegenerative Diseases2012/06/13English462
Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists2002/05/01English456
A New Benzodiazepine Pharmacology2002/01/01English456
Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure2002/08/01English454
The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity2003/04/03English445
Antifibrotic and Anti-inflammatory Activity of the Tyrosine Kinase Inhibitor Nintedanib in Experimental Models of Lung Fibrosis2014/02/20English441
A G Protein-Biased Ligand at theμ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine2013/01/08English437
Morphine Side Effects in β-Arrestin 2 Knockout Mice2005/05/25English437
Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs2002/12/01English428
Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D62004/05/24English424
Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action2007/03/19English417
Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease2008/04/16English398
Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Condition: A Suggested Solution Based on in Vivo Occupancy2003/02/20English386
R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation2006/08/31English385
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities2002/10/01English379
An Overview of Drug Combination Analysis with Isobolograms2006/05/02English361
Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma2006/05/25English360
Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. I. A Multivariate Analysis of the Binding Profiles of 14 Drugs at 21 Native and Cloned Human Receptor Subtypes2002/11/01English352
Functional Selectivity and Biased Receptor Signaling2010/10/28English352
Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans2004/05/24English351
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats2003/01/21English350