Nature Chemical Biology

Title Publication Date Language Citations
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO2011/10/16English2,571
Network pharmacology: the next paradigm in drug discovery2008/10/20English2,492
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury2005/05/29English2,021
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation2013/12/06English2,018
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition2016/11/14English1,956
Reconciling the chemistry and biology of reactive oxygen species2008/04/17English1,750
The role of iron and reactive oxygen species in cell death2013/12/17English1,550
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis2016/11/14English1,488
Networking by small-molecule hormones in plant immunity2009/04/17English1,440
Identification of RIP1 kinase as a specific cellular target of necrostatins2008/04/13English1,437
The role of dynamic conformational ensembles in biomolecular recognition2009/10/10English1,399
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli2009/06/28English1,329
Chemistry and biology of reactive oxygen species in signaling or stress responses2011/07/18English1,321
The function of terpene natural products in the natural world2007/06/18English1,256
Chemistry in living systems2005/06/01English1,133
Mass spectrometry–based proteomics turns quantitative2005/09/20English1,070
Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer2009/01/04English1,055
Mechanisms for copper acquisition, distribution and regulation2008/02/15English1,018
Targeting mitochondria metabolism for cancer therapy2014/12/17English983
Synthetic fluorescent sensors for studying the cell biology of metals2008/02/15English943
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors2005/08/14English941
Targeting virulence: a new paradigm for antimicrobial therapy2007/08/20English931
Rational design of inhibitors that bind to inactive kinase conformations2006/06/16English796
Foldamers as versatile frameworks for the design and evolution of function2007/04/16English775
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism2007/11/18English774
Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol2011/05/22English767
Catalytic in vivo protein knockdown by small-molecule PROTACs2015/06/10English765
RNAi therapeutics: a potential new class of pharmaceutical drugs2006/12/01English757
The role of iron regulatory proteins in mammalian iron homeostasis and disease2006/07/18English754
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects2008/11/23English708