Looking for a greener way to perform C5 nitration? This paper introduces a mild and efficient protocol for visible-light-photocatalyzed C5 nitration of 8-aminoquinoline derivatives. This is achieved using Cu(NO3)2∙3H2O as a nitro source, offering a sustainable alternative to traditional methods. The reaction proceeds smoothly under very mild conditions, utilizing Acid Red 94 as an organic photosensitizer and a common household light bulb as a light source. This significantly reduces the environmental impact and simplifies the operational process. The key to the protocol's success lies in the careful selection of the photocatalyst and light source, enabling high yields and selectivity without the need for harsh reagents or extreme conditions. Most products can be readily obtained through recrystallization, enhancing the operational simplicity of the procedure. This green and user-friendly approach holds considerable promise for widespread adoption in organic synthesis, fostering sustainable chemistry practices in academic and industrial laboratories.
Published in Catalysts, this paper fits squarely within the journal's focus on advancements in catalysis and sustainable chemistry. The development of a visible-light-photocatalyzed nitration method aligns with the journal's emphasis on environmentally friendly and efficient catalytic processes. This new protocol provides a practical and greener alternative to traditional nitration techniques, holding considerable promise for chemists seeking sustainable synthetic methods.