Want to unlock unprecedented insights into the human body's cellular landscape? This research introduces the Single Cell Atlas (SCA), a comprehensive multi-omics map of human tissues created through in-depth characterizations of single-cell sequencing datasets. This atlas integrates data from five single-cell omics, spatial transcriptomics, and bulk omics across 125 healthy adult and fetal tissues, providing a wealth of information about heterogeneous cell populations. Complementing the atlas is a user-friendly, web-based platform (www.singlecellatlas.org) designed to facilitate vast interactive data exploration. The platform allows researchers to delve into deep multi-omics signatures across human fetal and adult tissues, enabling them to uncover complex relationships between genes, proteins, and cell functions. This includes examining datasets from five single-cell omics, spatial transcriptomics, and two bulk omics. Designed as a one-stop, comprehensive resource, the SCA aspires to accelerate various omics studies by providing easy access to a wealth of information. The atlas and database queries are structured to save researchers time and effort, making it an invaluable tool for anyone seeking to understand the intricacies of human cellular biology and its implications for health and disease.
Published in Genome Biology, this research fits well with the journal’s emphasis on genetics, genomics, and biotechnology. By presenting a single-cell multi-omics map of human tissues, the study contributes significantly to the understanding of gene expression and cellular function at a genome-wide scale, aligning perfectly with the journal's scope.