Unraveling the intricate battle between Dengue virus and its host can lead to novel therapies. This review summarizes the complex interaction between DENV and host cellular machinery, highlighting regulatory mechanisms at various molecular levels. As a rapidly spreading viral disease, dengue necessitates a better understanding of the host-virus regulatory system to discover new therapeutic options. This review explores the epigenetic modulation of the host genome, transcription of host genes, translation of viral and host mRNAs, post-transcriptional regulation of the host transcriptome, post-translational regulation of viral proteins, and pathways involved in protein degradation. Dengue viruses (DENV) have developed several ways to modulate host metabolism to create an environment conducive to genome replication and the dissemination of viral progeny. Treatment is mostly restricted to supportive measures in the absence of a universally accepted prophylactic vaccine or therapeutic drug.
Published in the Journal of Biomedical Science, which has a wide focus across biological and medical research, this review aligns well with the journal's scope. The review provides a broad overview of the molecular mechanisms underlying Dengue virus pathogenesis, contributing to a deeper understanding of the virus-host interaction and potential therapeutic targets.