How is ceramide production regulated in relation to apoptosis? This review examines ceramide, a sphingosine-based lipid signaling molecule that influences cellular differentiation, proliferation, and apoptosis. Emerging research suggests that the coupling of ceramide to specific signaling cascades is both stimulus and cell-type specific. Ceramide action is influenced by the context of other stimuli and by the subcellular location of its production. The authors discuss the pathways of ceramide generation and its interaction with caspases and other apoptotic signaling cascades. These interactions are vital for proper cell function. By exploring the pathways of ceramide generation and its interplay with apoptotic signaling cascades, this review contributes to a broader understanding of cellular regulation and cell death mechanisms. This information could be important for disease treatments.
This review in the Annual Review of Physiology aligns with the journal's focus on cellular and molecular mechanisms underlying physiological processes. By examining the regulation of ceramide production and its role in apoptosis, the review contributes to the understanding of cellular signaling and its impact on cell fate.
| Category | Category Repetition |
|---|---|
| Science: Biology (General) | 202 |
| Science: Chemistry: Organic chemistry: Biochemistry | 200 |
| Science: Biology (General): Cytology | 124 |
| Medicine: Medicine (General) | 117 |
| Science: Biology (General): Genetics | 89 |