The high-affinity IgE receptor (FcεRI) plays a crucial role in linking IgEs with cellular immunologic effector functions. This review provides background information on FcεRI function, coupled with detailed summaries of recent progress in understanding specific aspects of FcεRI biology and biochemistry. Coordination and function of the large multiprotein signaling complexes. This receptor, a key member of the antigen (Ag) receptor superfamily, is responsible for triggering various immune responses, making it a critical focus in immunological research. It covers the coordination and function of the large multiprotein signaling complexes assembled when FcεRI and other Ag receptors are engaged and looks at information on human receptor structures and tissue distribution. The topics include the role of the FcRβ chain in signaling and its potential contribution to atopic phenotypes. This exploration of FcεRI provides crucial insights into immune responses and potential therapeutic targets for allergic and immunologic diseases, from physiology to pathology.
Appearing in the Annual Review of Immunology, this paper falls squarely within the journal’s focus on immunological research. It explores FcεRI in detail, linking it to allergic reactions and immunologic functions. Its discussion of human receptor structures aligns with the journal's emphasis on advancing knowledge in basic and clinical immunology.