How do eukaryotic cells ensure accurate genome duplication during cell division? This review synthesizes recent research to provide a coherent model of DNA replication initiation in eukaryotic cells. The opening question immediately establishes the significance of the review's topic. The review focuses on the ordered series of steps used to form key protein assemblies at origins of replication. It identifies many protein components and their assembly timing during the cell cycle. Despite differences in origin structure, the identity and assembly order of eukaryotic replication factors is highly conserved across species. By bringing together results from different organisms, the review provides a comprehensive understanding of eukaryotic DNA replication. It also emphasizes recent progress in determining the function of different replication factors once assembled at the origin. This model can inform future research on genome maintenance and cell cycle regulation.
Published in the Annual Review of Biochemistry, this review synthesizes recent findings on DNA replication, a fundamental process in biochemistry. The review provides a comprehensive overview of eukaryotic DNA replication. The focus on protein components and their assembly directly aligns with the journal’s biochemical scope.
| Category | Category Repetition |
|---|---|
| Science: Biology (General) | 546 |
| Science: Biology (General): Genetics | 496 |
| Science: Biology (General): Cytology | 403 |
| Science: Chemistry: Organic chemistry: Biochemistry | 343 |
| Science: Science (General) | 92 |