Is the key to understanding tissue development hidden in a single growth factor family? This paper illuminates the intricate TGF-β signal transduction network, a vital regulator of tissue development and homeostasis in metazoan organisms. It highlights how the receptors at the cell surface and the SMAD proteins orchestrate target gene transcription within the nucleus. This research delves into the multifunctional nature of TGF-β and related factors, explaining how distinct receptors, SMAD proteins, and DNA-binding partners operate in a cell-specific manner. By elucidating this complex network, the authors provide critical insights into the genetic causes of various forms of human cancer and developmental disorders. This paper significantly advances our understanding of the TGF-β pathway and its central role in health and disease. The findings pave the way for the development of novel therapeutic interventions targeting these pathways in cancer and developmental disorders, offering hope for more effective treatments.
Published in the Annual Review of Biochemistry, this paper aligns perfectly with the journal's focus on providing comprehensive reviews of significant research in biochemistry. The TGF-β pathway is a central signaling cascade, and this paper's detailed elucidation of its mechanisms contributes significantly to the journal's ongoing coverage of cellular regulation and its implications for human health.
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