Explore the multifaceted roles of matrix proteoglycans in human biology. This review synthesizes recent genetic and molecular studies, highlighting their influence on tissue organization, cell growth, and specialized tissue maturation. The authors discuss the structure-function relationships of proteoglycans, emphasizing novel aspects of their biology, examining genetic and molecular biological insights into proteoglycans secreted into the pericellular matrix. The article showcases how these molecules act as tissue organizers, influence cell growth, and impact various biological processes. Focusing on the protein core, the research delves into gene structure, transcriptional control, and functional roles, while providing a simplified nomenclature based on protein core design. The paper sheds light on how macrophages mobilize elastolytic cysteine proteases to accelerate collagen and elastin degradation at inflammation sites, relevant to conditions like atherosclerosis and emphysema. This comprehensive analysis highlights potential therapeutic avenues through specific cysteine protease inhibitors, holding promise for modifying immunity, osteoporosis, and chronic inflammation. By examining the molecular organization and functional roles, this work underscores the crucial importance of proteoglycans in maintaining tissue health and modulating cellular behavior.
Published in the Annual Review of Biochemistry, this paper aligns seamlessly with the journal's focus on providing comprehensive overviews of key biochemical topics. By focusing on matrix proteoglycans, their molecular design, and cellular functions, the review provides a valuable resource for researchers in biochemistry, molecular biology, and related fields. The in-depth analysis of structure-function relationships and novel aspects of proteoglycan biology further emphasizes the paper's significance within the journal's scope.
| Category | Category Repetition |
|---|---|
| Science: Biology (General) | 367 |
| Science: Chemistry: Organic chemistry: Biochemistry | 350 |
| Medicine: Medicine (General) | 288 |
| Science: Biology (General): Cytology | 189 |
| Medicine | 157 |