How is the migration and invasiveness of human trophoblast cells regulated during pregnancy? This study investigates the factors that control the movement and invasion of extravillous trophoblast (EVT) cells in the human placenta. EVT cells play a crucial role in establishing the placenta by migrating and invading the uterus and its vasculature. Using in vitro propagated normal first-trimester EVT cells, researchers found that growth factors, their binding proteins, extracellular matrix (ECM) components, and adhesion molecules regulate EVT cell migration/invasion in an autocrine/paracrine manner. Transforming growth factor β (TGF-β), decorin, and melanoma cell adhesion molecule (Mel-CAM) inhibit EVT cell migration, while insulin-like growth factor II (IGF-II), IGF-binding protein 1 (IGFBP-1), and endothelin 1 (ET-1) stimulate it. These findings provide insights into the complex regulation of human EVT cell migration and invasion, which is essential for normal placentation. Understanding these mechanisms may lead to better management of pregnancy-related disorders such as preeclampsia and trophoblastic neoplasms.
As a study of trophoblast migration and invasiveness, this paper is appropriate for the Canadian Journal of Physiology and Pharmacology. The journal publishes research in diverse areas of physiology and pharmacology, and this article contributes by exploring the cellular and molecular mechanisms underlying a key process in human reproduction. The focus on growth factors and cell adhesion molecules aligns with the journal’s scope.
| Category | Category Repetition |
|---|---|
| Science: Biology (General) | 36 |
| Science: Biology (General): Cytology | 28 |
| Science: Chemistry: Organic chemistry: Biochemistry | 23 |
| Medicine | 21 |
| Medicine: Medicine (General) | 17 |
| Category | Category Repetition |
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| Medicine: Medicine (General) | 71 |
| Medicine | 64 |
| Science: Biology (General) | 63 |
| Science: Biology (General): Reproduction | 55 |
| Medicine: Gynecology and obstetrics | 45 |