Disruption of Zfh3 abolishes mulberry‐specific monophagy in silkworm larvae

Article Properties
  • Language
    English
  • DOI (url)
    10.1111/1744-7917.13354
  • Publication Date
    2024/04/15
  • Journal
    Insect Science
  • Indian UGC (Journal)
  • Refrences
    54
  • Yunlong Zou State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China ORCID (unauthenticated)
  • Wentao Wu State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China
  • Tianfu Luo State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China
  • Yuxia Tang State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China
  • Hai Hu State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China
  • Aijun Ye State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China
  • Lifeng Xu State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China
  • Fangyin Dai State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China ORCID (unauthenticated)
  • Xiaoling Tong State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences Southwest University Chongqing China ORCID (unauthenticated)
Abstract
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Cite
Zou, Yunlong, et al. “Disruption of Zfh3 Abolishes mulberry‐specific Monophagy in Silkworm Larvae”. Insect Science, 2024, https://doi.org/10.1111/1744-7917.13354.
Zou, Y., Wu, W., Luo, T., Tang, Y., Hu, H., Ye, A., Xu, L., Dai, F., & Tong, X. (2024). Disruption of Zfh3 abolishes mulberry‐specific monophagy in silkworm larvae. Insect Science. https://doi.org/10.1111/1744-7917.13354
Zou Y, Wu W, Luo T, Tang Y, Hu H, Ye A, et al. Disruption of Zfh3 abolishes mulberry‐specific monophagy in silkworm larvae. Insect Science. 2024;.
Journal Categories
Agriculture
Animal culture
Agriculture
Plant culture
Science
Zoology
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Description

Can we alter insect feeding behavior by disrupting a single gene? This study investigates the role of the transcription factor Zfh3 in the monophagic feeding behavior of silkworm larvae, which primarily feed on mulberry leaves. Using CRISPR/Cas9 mutagenesis, the researchers disrupted the *Zfh3* gene to explore its impact on gustation and olfaction. Zfh3 was abrogated using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) mutagenesis. Since Zfh3 knockout homozygotes are not viable, we studied feeding behavior in heterozygotes, and found that disruption of Zfh3 affects both gustation and olfaction. Mutant larvae lost preference for mulberry leaves and acquired the ability to consume a broader range of diets, showing improved adaptation to an artificial diet without mulberry leaves. This demonstrates that a transcription factor can modulate feeding behaviors in an insect. These findings shed light on the genetic basis of insect feeding preferences, providing new avenues for understanding and potentially manipulating insect-plant interactions.

This study, appearing in Insect Science, fits the journal's focus on insect biology, behavior, and genetics. The research examines the genetic mechanisms underlying feeding behavior in silkworms, providing insights into insect-plant interactions. Which is inline with the focus of the journal.

Refrences
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Refrences Analysis
Category Category Repetition
Science: Biology (General)32
Science: Zoology17
Science: Biology (General): Cytology16
Science: Biology (General): Genetics12
Agriculture: Plant culture10
The category Science: Biology (General) 32 is the most frequently represented among the references in this article. It primarily includes studies from Developmental Biology The chart below illustrates the number of referenced publications per year.
Refrences used by this article by year