Can astrocyte function be the key to understanding brain state modulation? This paper explores the role of astrocytes, particularly focusing on chloride (Cl-) homeostasis, in regulating brain states such as sleep and wakefulness. It acknowledges that while various parameters and data delineate brain states, the underlying mechanisms remain unclear. The study highlights astrocytes' proficiency in maintaining dynamic ion homeostasis (ionostasis) and emphasizes the significance of astrocyte-driven ionostasis in the context of brain states. The objective is to underscore the importance of astrocytic Cl- homeostasis, elucidating its potential role in modulating brain states. This research seeks to contribute to a more comprehensive understanding of the interplay between astrocytes and brain states, potentially opening new avenues for pharmacological interventions targeting sleep disorders and related conditions.
This paper's focus on astrocytes and chloride homeostasis aligns with the journal's emphasis on cellular and molecular biology. The study of how these mechanisms modulate brain states is relevant to the journal's scope. By exploring the interplay between astrocytes and brain states, the research contributes to a broader understanding of neurological processes.