Title	Publication Date	Language	Citations
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.	1993/04/01	English	1,010
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails	2001/09/15	English	1,007
RANK is essential for osteoclast and lymph node development	1999/09/15	English	1,002
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	2001/10/15	English	991
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint	2000/06/15	English	990
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFβ-TRCP	2010/01/01	English	990
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.	1995/07/01	English	977
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex	2004/11/15	English	972
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells	2002/04/15	English	969
New functional activities for the p21 family of CDK inhibitors.	1997/04/01	English	969
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins	2005/05/18	English	953
A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana	2006/12/15	English	946
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.	1991/09/01	English	943
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis	2011/02/11	English	936
Autophagy-deficient mice develop multiple liver tumors	2011/04/15	English	933
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism	1999/06/01	English	927
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions	2006/04/17	English	926
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.	1997/01/01	English	926
The emerging role of the Nrf2–Keap1 signaling pathway in cancer	2013/10/15	English	923
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling	1999/04/15	English	921
The complexity of p53 modulation: emerging patterns from divergent signals	1998/10/01	English	916
Mitochondrial dynamics and apoptosis	2008/06/15	English	916
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function	2004/02/15	English	913
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction	2006/11/01	English	911
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability	2000/10/01	English	902
Proteases to die for	1998/06/01	English	895
The Hippo pathway: regulators and regulations	2013/02/15	English	884
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis	2002/07/15	English	876
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.	1996/06/15	English	873
Mutant p53: one name, many proteins	2012/06/15	English	872