Drug Metabolism and Disposition

Title Publication Date Language Citations
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS2004/08/27English1,277
ACETAMINOPHEN-INDUCED HEPATOTOXICITY2003/11/18English703
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS2004/08/10English640
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”2006/02/07English578
Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite2009/10/07English570
COMPARISON OF PRIMARY HUMAN HEPATOCYTES AND HEPATOMA CELL LINE HEPG2 WITH REGARD TO THEIR BIOTRANSFORMATION PROPERTIES2003/07/16English558
THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE2003/07/01English550
The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans2007/11/15English505
EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS2005/10/04English489
COMPARISON OF INHIBITORY EFFECTS OF THE PROTON PUMP-INHIBITING DRUGS OMEPRAZOLE, ESOMEPRAZOLE, LANSOPRAZOLE, PANTOPRAZOLE, AND RABEPRAZOLE ON HUMAN CYTOCHROME P450 ACTIVITIES2004/07/16English450
Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans2008/10/02English428
Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines2007/05/11English409
Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation2015/06/03English400
VALIDATED ASSAYS FOR HUMAN CYTOCHROME P450 ACTIVITIES2004/05/20English385
DEGRADATION OF GINSENOSIDES IN HUMANS AFTER ORAL ADMINISTRATION2003/07/16English352
In Vitro P-glycoprotein Assays to Predict the in Vivo Interactions of P-glycoprotein with Drugs in the Central Nervous System2007/10/25English347
Comparative Metabolic Capabilities of CYP3A4, CYP3A5, and CYP3A72002/08/01English338
Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions2006/11/08English337
Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities2011/10/12English337
Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction2008/10/06English335
CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes2002/07/01English320
Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification2015/08/21English311
THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL2004/10/22English310
Structure and Stereochemistry of the Active Metabolite of Clopidogrel2002/11/01English309
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds2008/04/21English300
Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption2009/05/21English296
Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?2014/02/03English290
The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties2002/12/01English287
Absorption and Disposition of Ginsenosides after Oral Administration of Panax notoginseng Extract to Rats2009/09/28English286
Metabolism and Excretion of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Rats, Dogs, and Humans2009/02/05English282