Clinical Epigenetics

Title Publication Date Language Citations
Statistical predictions with glmnet2019/08/23English405
The role and mechanisms of action of microRNAs in cancer drug resistance2019/02/11English403
Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage2018/04/23English362
Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors2012/03/12English347
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort2016/06/03English333
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy2010/11/09English283
DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies2015/10/16English271
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy2016/05/24English259
Sirtuin functions and modulation: from chemistry to the clinic2016/05/25English243
The epigenetic effects of butyrate: potential therapeutic implications for clinical practice2012/02/27English236
The timeline of epigenetic drug discovery: from reality to dreams2019/12/01English212
Differences in smoking associated DNA methylation patterns in South Asians and Europeans2014/02/03English198
Frailty is associated with the epigenetic clock but not with telomere length in a German cohort2016/02/26English195
Air pollution and DNA methylation: effects of exposure in humans2019/09/03English189
Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases2015/10/16English183
Epigenetic therapy for ovarian cancer: promise and progress2019/01/15English155
The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis2019/04/11English154
The emerging role of epigenetics in human autoimmune disorders2019/02/26English150
Epigenetic treatment of solid tumours: a review of clinical trials2015/12/01English147
Epigenetic targets of bioactive dietary components for cancer prevention and therapy2010/09/18English145
Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence2015/04/29English139
Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy2013/02/01English135
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells2011/10/26English132
Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma2018/02/09English132
Histone acetyltransferases: challenges in targeting bi-substrate enzymes2016/05/26English130
DNA methylation: conducting the orchestra from exposure to phenotype?2016/09/06English127
Changes in DNA methylation at the aryl hydrocarbon receptor repressor may be a new biomarker for smoking2013/10/11English127
Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study2016/05/06English126
Recent developments on the role of epigenetics in obesity and metabolic disease2015/07/11English126
Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease2015/03/14English124