Alternatives to Laboratory Animals

Title Publication Date Language Citations
The Practical Application of Three Validated In Vitro Embryotoxicity Tests2006/10/01English64
Validation of the Postimplantation Rat Whole-embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests2004/09/01English63
Reconstructed Human Epidermis for Skin Absorption Testing: Results of the German Prevalidation Study2006/06/01English63
Detection of Oxidised Purines and UV-induced Photoproducts in DNA of Single Cells, by Inclusion of Lesion-specific Enzymes in the Comet Assay1996/06/01English62
Biomarkers as Predictive Tools in Toxicity Testing2000/01/01English59
Selection of Test Chemicals for the ECVAM International Validation Study on In Vitro Embryotoxicity Tests2002/03/01English56
Methods for Assessing Percutaneous Absorption1996/01/01English53
Systematic Reviews of Animal Experiments Demonstrate Poor Human Clinical and Toxicological Utility2007/12/01English50
The Adverse Outcome Pathway Concept: A Basis for Developing Regulatory Decision-making Tools2016/10/01English49
Applications of the Neutral Red Cytotoxicity Assay toIn VitroToxicology1990/11/01English47
Testing Acute Toxicity in the Embryo of Zebrafish, Brachydanio rerio, as an Alternative to the Acute Fish Test: Preliminary Results1994/01/01English46
Development of the EpiOcular™ Eye Irritation Test for Hazard Identification and Labelling of Eye Irritating Chemicals in Response to the Requirements of the EU Cosmetics Directive and REACH Legislation2011/09/01English45
Chemical Respiratory Allergy: Opportunities for Hazard Identification and Characterisation2007/05/01English45
The Response of a Co-culture Lung Model to Fine and Ultrafine Particles of Incinerator Fly Ash at the Air–liquid Interface2008/07/01English44
MEIC Evaluation of Acute Systemic Toxicity1998/08/01English43
Hallmarks of Atopic Skin Mimicked In Vitro by Means of a Skin Disease Model Based on FLG Knock-down2011/10/01English43
Dendritic Cells as a Tool for the Predictive Identification of Skin Sensitisation Hazard2005/02/01English43
An Approach to Determining Applicability Domains for QSAR Group Contribution Models: An Analysis of SRC KOWWIN2005/10/01English43
ECVAM Good Cell Culture Practice Task Force Report 12002/07/01English42
Cytotoxicity Assays with Fish Cells as an Alternative to the Acute Lethality Test with Fish2004/10/01English42
Prediction of Acute Aquatic Toxicity toward Daphnia Magna by using the GA-kNN Method2014/03/01English42
TheIn VitroAcute Skin Irritation of Chemicals: Optimisation of the EPISKIN Prediction Model within the Framework of the ECVAM Validation Process2005/08/01English41
In SilicoToxicology in Drug Discovery — Concepts Based on Three-dimensional Models2009/11/01English39
Practical Aspects of the Validation of Toxicity Test Procedures1995/01/01English39
The Second ECVAM Workshop on Phototoxicity Testing2000/11/01English38
A Human Corneal Equivalent Constructed from SV40-immortalised Corneal Cell Lines2005/02/01English38
A Comparative Evaluation of Corneal Epithelial Cell Cultures for Assessing Ocular Permeability2008/02/01English38
Skin Sensitisation and Epidermal Disposition: The Relevance of Epidermal Disposition for Sensitisation Hazard Identification and Risk Assessment2007/03/01English37
In Vitro Skin Irritation Testing: Improving the Sensitivity of the EpiDerm Skin Irritation Test Protocol2009/12/01English37
The Ex Vivo Skin Model as an Alternative Tool for the Efficacy and Safety Evaluation of Topical Products2020/01/01English36