Title	Publication Date	Language	Citations
An epigenetic biomarker of aging for lifespan and healthspan	2018/04/18	English	1,233
Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies	2016/03/27	English	907
DNA methylation GrimAge strongly predicts lifespan and healthspan	2019/01/21	English	881
Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis	2020/04/08	English	761
DNA methylation-based measures of biological age: meta-analysis predicting time to death	2016/09/28	English	599
Why does COVID-19 disproportionately affect older people?	2020/05/29	English	568
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463	2017/03/08	English	414
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors	2017/02/14	English	413
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging	2011/03/10	English	410
Role of Apoptosis in disease	2012/05/31	English	366
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy	2010/12/29	English	360
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle	2009/08/15	English	335
Polyamines in aging and disease	2011/08/21	English	334
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8	2009/04/21	English	331
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies	2018/07/26	English	303
Inflammaging: disturbed interplay between autophagy and inflammasomes	2012/03/07	English	299
Markers of cellular senescence. Telomere shortening as a marker of cellular senescence	2016/01/23	English	282
Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning	2015/12/18	English	281
Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990–2017: results from a global burden of disease study, 2017	2019/12/02	English	270
Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis	2020/07/13	English	261
Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients	2015/12/09	English	259
Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1	2020/06/29	English	240
Fasting and cancer treatment in humans: A case series report	2009/12/31	English	234
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells	2016/07/06	English	234
ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy	2020/06/05	English	228
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues	2012/12/29	English	222
p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli	2017/08/02	English	218
Age-related changes in microRNA levels in serum	2013/09/27	English	217
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues	2013/12/07	English	212
Functional metagenomic profiling of intestinal microbiome in extreme ageing	2013/12/10	English	209