Chemical Research in Toxicology

Title Publication Date Language Citations
Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress1992/03/01English2,110
Mechanistic Applicability Domain Classification of a Local Lymph Node Assay Dataset for Skin Sensitization2007/06/08English1,310
Role of Quinones in Toxicology2000/02/23English1,157
Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity2001/05/05English1,144
Cytochrome P450 and Chemical Toxicology2007/12/06English1,078
Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes2008/08/19English984
Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review2011/10/21English964
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide1992/11/01English892
Structure, Catalytic Mechanism, and Evolution of the Glutathione Transferases1997/01/01English844
Biochemistry, Biology, and Carcinogenicity of Tobacco-Specific N-Nitrosamines1998/06/01English770
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects1991/03/01English765
Chromium in Drinking Water: Sources, Metabolism, and Cancer Risks2011/07/28English744
Oxidative Damage and Tyrosine Nitration from Peroxynitrite1996/01/01English719
Metabolism and Kinetics of Bisphenol A in Humans at Low Doses Following Oral Administration2002/09/24English715
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes1991/07/01English656
Absolute Rate Constants for the Reaction of Hypochlorous Acid with Protein Side Chains and Peptide Bonds2001/09/11English647
Nanotoxicity of Graphene and Graphene Oxide2014/01/14English621
Genetic and Epigenetic Mechanisms in Metal Carcinogenesis and Cocarcinogenesis: Nickel, Arsenic, and Chromium2007/10/30English595
Oxidative Stress and Neurotoxicity2007/12/04English571
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor2007/12/13English537
Drug−Protein Adducts:  An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development2003/12/12English504
Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease1997/05/01English497
Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States2011/07/11English485
The Less Harmful Cigarette:  A Controversial Issue. A Tribute to Ernst L. Wynder2001/06/28English466
Integrated Metabonomic Analysis of the Multiorgan Effects of Hydrazine Toxicity in the Rat2005/01/25English456
Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis1997/11/01English425
Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings2002/02/07English413
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions1992/01/01English399
ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology2016/07/20English389
Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety2011/07/26English382