| First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's Disease | 2002/02/13 | English | 347 |
| Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation | 2002/03/13 | English | 346 |
| Druggability Indices for Protein Targets Derived from NMR-Based Screening Data | 2005/02/24 | English | 345 |
| Derivation and Validation of Toxicophores for Mutagenicity Prediction | 2004/12/17 | English | 344 |
| Structure−Activity Relationships of Pyrazole Derivatives as Cannabinoid Receptor Antagonists | 1999/02/01 | English | 343 |
| Detailed Analysis of Scoring Functions for Virtual Screening | 2001/03/01 | English | 342 |
| L-N6-(1-Iminoethyl)lysine: A Selective Inhibitor of Inducible Nitric Oxide Synthase | 1994/11/01 | English | 340 |
| Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery | 1997/12/01 | English | 339 |
| Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions | 2016/12/20 | English | 339 |
| Dihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines | 1990/09/01 | English | 338 |
| Validation and Use of the MM-PBSA Approach for Drug Discovery | 2005/05/10 | English | 337 |
| Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment | 2014/11/14 | English | 337 |
| Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds | 2017/10/17 | English | 337 |
| Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors | 2002/03/26 | English | 336 |
| MetaSite: Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist | 2005/09/30 | English | 335 |
| Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism | 2019/08/13 | English | 334 |
| Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases | 2017/02/10 | English | 330 |
| Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib: New Pharmacological Opportunities Due to Related Binding Site Recognition | 2003/12/18 | English | 329 |
| Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics? | 2018/02/15 | English | 329 |
| 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer | 2007/11/20 | English | 328 |
| Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides | 1972/11/01 | English | 327 |
| Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications | 2015/05/14 | English | 326 |
| Functional group contributions to drug-receptor interactions | 1984/12/01 | English | 324 |
| Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines | 2002/04/17 | English | 324 |
| Studies on 1,2,3-triazoles. 13. (Piperazinylalkoxy)-[1]benzopyrano[2,3-d]-1,2,3-triazol-9(1H)-ones with combined H1-antihistamine and mast cell stabilizing properties | 1986/11/01 | English | 323 |
| Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential | 1992/02/01 | English | 322 |
| 2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents | 1979/07/01 | English | 321 |
| U.S. FDA Approved Drugs from 2015–June 2020: A Perspective | 2021/02/22 | English | 321 |
| Bis(maltolato)oxovanadium(IV) is a potent insulin mimic | 1992/04/01 | English | 320 |
| Conformational Analysis of Drug-Like Molecules Bound to Proteins: An Extensive Study of Ligand Reorganization upon Binding | 2004/04/07 | English | 319 |