Journal of Medicinal Chemistry

Title Publication Date Language Citations
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses2017/01/26English445
Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice1995/06/01English444
Applications of Deuterium in Medicinal Chemistry2019/01/14English443
Ligands for Glutamate Receptors:  Design and Therapeutic Prospects2000/07/01English437
4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-12008/09/19English436
Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept2017/01/17English435
Recent Developments in Fragment-Based Drug Discovery2008/07/01English434
Oxadiazoles in Medicinal Chemistry2012/01/13English433
Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance2007/01/19English433
Histone Deacetylase Inhibitors2003/10/28English432
A Specific Mechanism of Nonspecific Inhibition2003/08/22English431
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors:  Safinamide and Coumarin Analogs2007/10/04English428
Quadruplex Nucleic Acids as Novel Therapeutic Targets2016/02/16English427
Fragment-Based Drug Discovery2004/06/04English427
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors1989/10/01English426
Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond1989/07/01English423
Binding of a Diverse Set of Ligands to Avidin and Streptavidin:  An Accurate Quantitative Prediction of Their Relative Affinities by a Combination of Molecular Mechanics and Continuum Solvent Models2000/09/09English423
Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases2014/01/23English422
Intramolecular Hydrogen Bonding in Medicinal Chemistry2010/02/22English422
Consensus Scoring:  A Method for Obtaining Improved Hit Rates from Docking Databases of Three-Dimensional Structures into Proteins1999/11/25English420
Neuronal Nicotinic Acetylcholine Receptors:  Structural Revelations, Target Identifications, and Therapeutic Inspirations2005/07/01English418
Current concepts in antisense drug design1993/07/01English417
Nitric Oxide: A New Paradigm for Second Messengers1995/10/01English416
Antitumor Benzothiazoles. 26. 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a Simple Fluorinated 2-Arylbenzothiazole, Shows Potent and Selective Inhibitory Activity against Lung, Colon, and Breast Cancer Cell Lines2005/12/02English416
Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR2000/07/22English415
Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry2011/02/23English415
Evaluation of Docking Performance:  Comparative Data on Docking Algorithms2003/12/31English414
A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides2004/05/12English413
Tumor inhibitors. 69. Structure-cytotoxicity relations among the sesquiterpene lactones1971/12/01English411
Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?2013/09/17English408