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Genes to Cells
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One of the highlights of the month of July in Japan is Tanabata (Star Festival). Tanabata, a festival to pray to the stars in the Milky Way in summer, was imported from ancient China. People in Edo era started to decorate bamboo branches with ‘tanzaku’ (small pieces of paper) on which they wrote their wishes, and to pray the wishes would come true. The bamboo branches in this drawing are likened to histone tails (H2A, H2B, H4 and H3 from the left). The tanzakus represent epigenetic modifi cations (acetylation, methylation and phosphorylation) of amino acid residues in histone tails. If you use this histone bamboo, mind that you have to phrase your wishes with the types, positions and combinations of decorations (or modifications). You need a textbook to perform modifi cations correctly. Designed by TRAIS Co., Ltd. (Kobe, Japan)
2015/07/01
English
Genome editing technologies have been invented and improved in recent years, and there is a growing expectation that the technologies can be utilized as a tool not only for molecular biological studies, but also for genetic therapies. Among them, CRISPR‐Cas9 system that was originally found as a part of the bacterial adaptive immune system gets noticed for its easy introduction. Here, users are only required to design a guide RNA with a 20‐nt sequence that is complementary to the target DNA sequence and co‐express Cas9 with the RNA in vivo, then Cas9 protein will cleave the target DNA in a site‐specific manner. This is a portrait of a kabuki actor who plays Cas9 as indicated by the crest “ku” (‘nine’) on kimono he is wearing. The “actor” definitely has a promising future ahead of him. Designed by TRAIS Co., Ltd. (Kobe, Japan)
2015/04/01
English
Erratum
2006/07/19
English
Volume Contents
2008/12/01
English
Index
2008/12/01
English
Index
2004/11/25
English
Erratum
2009/03/25
English
Editorial
2005/12/21
English
Erratum
2007/06/20
English
Issue Information
2016/01/01
English
Worship the first sunrise of the new year from two rocks ‘Meoto‐iwa’ (the wedded rocks, Mie, Japan) under double‐helical DNA‐like contrails in the sky. From left to right, there is the big rock, the sacred straw rope, the smaller rock, and the multi‐exposed chain of suns. They just look like an RNA polymerase transcribing DNA into mRNA, its resultant mRNA, a ribosome translating the mRNA, and the new polypeptide chain growing upward from the ribosome, respectively. Designed by TRAIS Co., Ltd. (Kobe, Japan).
2016/01/01
English
Issue Information
2017/10/01
English
Issue Information
2016/04/01
English
Corrigendum
2017/01/01
English
Issue Information
2017/01/01
English
Issue Information
2017/08/01
English
Issue Information
2017/05/01
English
Erratum
2017/06/01
English
Issue Information
2017/06/01
English
Assembly of insect hormone enthusiasts at Nasu Highland, Japan: Report of the 3rd International Insect Hormone (21st Ecdysone) Workshop
2017/11/29
English
Issue Information
2018/03/01
English
Announcement
2018/03/01
English
Issue Information
2016/11/01
English
Impacts of methotrexate on survival, dendrite development, and synapse formation of cortical neurons
2023/05/12
English
The iron chelator deferriferrichrysin induces paraptosis via extracellular signal‐related kinase activation in cancer cells
2023/06/01
English
The toxicity of dysregulated Plk1 activity revealed by its suppressor mutations
2023/04/29
English
Multiple pathways and independent functional pools in insulin granule exocytosis
2023/04/18
English
Squamous cell carcinoma‐derived G‐CSF promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients
2023/05/29
English
Premature gray hair development in the interbrow region owing to the loss of maxillary first molars in young mice
2024/02/20
English
Left–right Myosin‐Is, Myosin1C, and Myosin1D exhibit distinct single molecule behaviors on the plasma membrane of Drosophila macrophages
2024/03/07
English
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