Perspectives in Drug Discovery and Design

Title Publication Date Language Citations
Site-directed structure generation by fragment-joining1995/12/01English
Accomplishments and challenges in integrating software for computer-aided ligand design in drug discovery1995/12/01English
Recombinant human protein C, protein S and thrombomodulin as antithrombotics1994/04/01English
Random chemistry1995/04/01English
RNA targeting by the HIV-1 Tat protein1993/08/01English
Mechanism of action of heparin and heparin-like antithrombotics1994/04/01English
Three-dimensional models for integral membrane proteins: Possibilities and pitfalls1993/12/01English
Neutralization epitopes on HIV pseudotyped with HTLV-I1996/12/01English
Competitive inhibitors of human immunodeficiency virus reverse transcriptase1993/08/01English
Rapamycin: Biological and therapeutic effects, binding by immunophilins and molecular targets of action1994/08/01English
Synthetic combinatorial libraries: Views on techniques and their application1995/04/01English
Soluble analogs of GalCer and suramin as potential inhibitors of HIV-1 infection: Key role of self-association1996/12/01English
Suramin: A polysulfonated compound that inhibits the binding of HIV-1 gp120 to GalCer/sulfatide and blocks the CD4-independent pathway of HIV-1 infection in mucosal epithelial cells1996/12/01English
Substrate-based inhibitors of HIV-1 protease1993/08/01English
Antisense oligodeoxynucleotides: Internalization, compartmentalization and non-sequence specificity1996/12/01English
The role of the envelope glycoproteins in HIV-1 transmission and pathogenesis1996/12/01English
Possible role of nonprotein components of the plasma membrane in CD4-dependent membrane fusion and HIV entry1996/12/01English
HIV-permissive cells from solid tissues: Cytokine induction and effects1996/12/01English
PNP inhibitors1994/08/01English
Backward binding and other structural surprises1995/12/01English
Aspartic proteinases: The structures and functions of a versatile superfamily of enzymes1995/07/01English
The integrin αIIbβ3 as an antithrombotic target1994/04/01English
The medicinal chemistry of FK-5061994/08/01English
Crystal structures of thrombin and thrombin complexes as a framework for antithrombotic drug design1994/04/01English
MyristolyCoA:protein N-myristoyltransferase as a therapeutic target for inhibiting replication of human immunodeficiency virus-11993/08/01English
NMR for structural studies in drug discovery1995/12/01English
Cyclosporin A and FK-506: Immunosuppression, inhibition of transcription and the role of calcineurin1994/08/01English
Genetic determinants controlling HIV-1 tropism for CD4−/GalCer+ human intestinal epithelial cells1996/12/01English
Interactions of the human immunodeficiency virus with astrocytes1996/12/01English
HIV-1 infection of a CD4-negative primary cell type: The oligodendrocyte1996/12/01English